PH2070 Introduction to Biophysics

Course Details

Course Contents :
Total lecture hours: 40 (estimated number for each unit given in brackets). 1).The living cell as a physical system. (3) Thermodynamic foundations, Structure and organisation of the cell, molecular forces 2). Review of Thermodynamics and Probability (5) Thermodynamic potentials, Random variables, Gaussian and Poisson distributions, fluctuations 3). Entropy and Free Energy (5) Entropic forces in the cell, rectification of fluctuations, osmotic flow, self-assembly. 4). Biological applications of diffusion (5) Brownian motion, Fick?s law, diffusion in one and higher dimensions, biological examples of random walks 5). Hydrodynamics (5) Viscosity, friction and dissipation, Reynolds number, biological applications: pumping, stirring and swimming 6). Chemical kinetics and enzymes (5) Chemical reactions, binding and dissociation, diffusion limited association, Kramers? theory, Michaelis-Menten kinetics, molecular motors 7). Structure and mechanics (5) Hooke?s law, elastic models of polymers and membranes, bending and stretching of DNA 8). Mathematical Biology (5) Differential equation models, instability and bifurcations, reaction diffusion systems, pattern formation, chemotaxis

Course References:

? Biological Physics: Energy, Information, Life, Philip Nelson (W. H. Freeman and ? Company, 2004) ? Molecular and Cellular Biophysics, Meyer B. Jackson (Cambridge University Press, 2006) ? Physical Biology of the Cell, Phillips, Kondev and Theriot (Garland Science, 2009) ? Random walks in Biology, H. Berg (Princeton University Press, 1993) ? Molecular Biology of the Cell, B. Alberts et al. (Garland Science, 4th ed, 2002) ? Mathematical Biology: I. An Introduction, J. D. Murray (Springer, 2007) ? Pattern Formation and Dynamics in Nonequilibrium Systems, M. Cross and H. Greenside ? (Cambridge University Press, 2009)