Detection Of Base-Pair Mismatches In Double-Stranded DNA Via Nanopore Sequencing: A New Beginning

2022-01-05 Dr. Sourav Kundu, Techno India University, Kolkata

ABSTRACT :

We present a unique way to detect base-pair mismatches in DNA, leading to a different epigenetic disorder by the method of nanopore sequencing. Based on a tight-binding formulation of a graphene nanopore device, using the Green’s function approach we study the changes in the electronic transport properties of the device as a double-stranded DNA translocate through the nanopore embedded in a zigzag graphene nanoribbon. In the present work we are not only successful in detecting the usual AT and GC pairs but also a set of possible mismatches in the complementary base pairing.

Event Name

Seminars

Place

Online

Start Time

15:00

End Time

16:00

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